Lot's Wife is a modern day tale of Sodom and Gomorrah set in a shantytown located on the outskirts of Istanbul, Turkey. Mehmet is a young hardworking guy who lives in a small house that belongs to his uncle Seyfeddin. Unbeknownst to Seyfeddin, Mehmet is living with his lover Ali. On one summer day, Seyfeddin along with his wife Meryem, and two brothers, Hidir and Mikail barge into Mehmet's apartment, threatening to destroy everything he hopes for and had created with Ali so far.